MPN - Myeloproliferativeneoplasm network

Primary Myelofibrosis

What is Polycythaemia vera

Primary myelofibrosis (PMF) is a rare, chronic disorder in which the development of fibrosis in the bone marrow interferes with blood cell production, which can lead to anaemia, bleeding, and enlargement of the spleen and liver.

The outlook for patients diagnosed with PMF depends on multiple factors; some individuals remain symptom-free without intervention for many years, whereas others require aggressive treatment


PMF arises due to genetic mutations in bone marrow stem cells, but the cause of these changes is unknown.


The clinical signs and symptoms of PMF include:

Complications include bleeding, thrombosis, and progression to acute leukaemia, the latter occurring in approximately 20% of patients.


Clinical and laboratory parameters are assessed according to the 2016 World Health Organisation (WHO) diagnostic criteria, which distinguish a pre-fibrotic and an overtly fibrotic stage of the disease.

All of the following major criteria for must be met for diagnosis of PMF:

Additionally, one of the following minor WHO criteria must be met:

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Other MPN

Essential Thrombocythaemia

Essential thrombocythaemia (ET) is a disease of the bone marrow, characterised by a pronounced increase of the number of platelets (thrombocytes) in the blood. 

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Chronic myeloid leukaemia
Other MPN

Chronic myeloid leukaemia

Die chronische myeloische Leukämie (CML) ist eine Blutkrebsart, die zur Gruppe der myeloproliferativen Neoplasien gehört. Sie ist gekennzeichnet durch ein unreguliertes Wachstum von myeloischen Zellen im Knochenmark, was zu einer erhöhten Anzahl bestimmter weißer Blutkörperchen im Blut führt.

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